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Evaluation of Efficacy and Safety of Pamrevlumab in Patients With Idiopathic Pulmonary Fibrosis

Study Purpose

This is a Phase 3 trial to evaluate the efficacy and safety of 30 mg/kg intravenous (IV) infusions of pamrevlumab administered every 3 weeks as compared to placebo in subjects with Idiopathic Pulmonary Fibrosis

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 40 Years - 85 Years
Gender All
More Inclusion & Exclusion Criteria

Key

Inclusion Criteria:

1. Diagnosis of IPF as defined by ATS/ERS/JRS/ALAT guidelines (Raghu 2018) within the past 7 years prior to study participation. 2. HRCT scan at Screening, with ≥10% to <50% parenchymal fibrosis (reticulation) and <25% honeycombing. 3. FVCpp value >45% and <95% 4. Diffusing capacity of the lungs for carbon monoxide (DLCO) percent predicted ≥25% and ≤90% at screening (determined locally). 5. Not currently receiving treatment for IPF with an approved therapy (i.e., pirfenidone or nintedanib) for any reason, including prior intolerance to an approved IPF therapy. Key

Exclusion Criteria:

1. Previous exposure to pamrevlumab. 2. Evidence of significant obstructive lung disease. 3. Female subjects who are pregnant or nursing. 4. Smoking within 3 months of Screening and/or unwilling to avoid smoking throughout the study. 5. Interstitial lung disease other than IPF. 6. Sustained improvement in the severity of IPF. 7. Other types of respiratory diseases including diseases of the airways, lung parenchyma, pleural space, mediastinum, diaphragm, or chest wall. 8. Certain medical conditions, including recent (e.g. MI/stroke, or severe chronic heart failure or pulmonary hypertension, or cancers. 9. Acute IPF exacerbation during Screening or Randomization. 10. Recent use of any investigational drugs or unapproved therapies, or approved or participation in any clinical trial. 11. History of allergic or anaphylactic reaction to human, humanized, chimeric or murine monoclonal antibodies.

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT03955146
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase 3
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

FibroGen
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

N/A
Principal Investigator Affiliation N/A
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Industry
Overall Status Recruiting
Countries Argentina, Australia, Chile, China, Czechia, France, Germany, Hong Kong, Hungary, Italy, Korea, Republic of, Lebanon, Netherlands, Peru, Russian Federation, Spain, Taiwan, United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Idiopathic Pulmonary Fibrosis
Additional Details

This is a Phase 3, randomized, double-blind, placebo-controlled, multi-center trial to evaluate the efficacy and safety of pamrevlumab in subjects with idiopathic pulmonary fibrosis (IPF). Subjects who are not being treated with approved IPF therapies (i.e., nintedanib or pirfenidone) may be eligible for screening. Examples of reasons subjects may not be treated with approved IPF therapies include but are not limited to:

  • - Intolerant or not responsive to approved IPF therapies.
  • - Ineligible to receive these therapies.
  • - Subject voluntarily declines to receive approved IPF therapies after being fully informed of the potential benefits/risks.
NOTE: No subject should discontinue an approved IPF therapy for the purpose of enrolling in this study. Approximately 340 eligible subjects will be randomized at a 1:1 ratio to Arm A or Arm B, respectively: Arm A: pamrevlumab, 30 mg/kg IV, Day 1 and every 3 weeks thereafter. Arm B: Matching placebo IV, Day 1 and every 3 weeks thereafter. The study consists of the following study periods:
  • - Main (double blind, placebo-controlled) phase: - Screening period: Up to 6 weeks.
  • - Treatment period: 48 weeks.
  • - Optional, open label extension (OLE) phase of pamrevlumab: o Access to pamrevlumab will be available until the last subject completes 48 weeks of treatment in the OLE phase, or pamrevlumab is commercially available for the indication of IPF, or the Sponsor decides to end the OLE phase, whichever occurs first.
  • - Follow-up period/final safety assessments: - 28 days after last dose.
  • - 60 days after last dose: follow-up phone call, for a final safety assessment.
During the treatment period, co-administration of an approved IPF therapy (i.e., pirfenidone or nintedanib) is acceptable if clinically indicated in the Investigator's opinion, provided that the Investigator assesses the potential risks/benefits of combining approved IPF therapies with blinded study treatment. Subjects who discontinue study treatment for any reason should be encouraged to remain in the study and be followed for all study visits and assessments. Subjects who complete the study will be eligible for an open-label, extension with pamrevlumab.

Arms & Interventions

Arms

Experimental: Pamrevlumab

Experimental: Placebo

Interventions

Drug: - Pamrevlumab

Pamrevlumab: 30 mg/kg by intravenous infusion every 3 weeks for a total of 17 infusions over 48 weeks

Drug: - Placebo

Placebo: 30 mg/kg by intravenous infusion every 3 weeks for a total of 17 infusions over 48 weeks

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Birmingham, Alabama

Status

Recruiting

Address

University of Alabama at Birmingham Hospital

Birmingham, Alabama, 35294

Phoenix, Arizona

Status

Not yet recruiting

Address

Banner University Medical Center - Phoenix

Phoenix, Arizona, 85006

Norton Thoracic Institute, Phoenix, Arizona

Status

Recruiting

Address

Norton Thoracic Institute

Phoenix, Arizona, 85013

Pulmonary Associates, PA - Research, Phoenix, Arizona

Status

Recruiting

Address

Pulmonary Associates, PA - Research

Phoenix, Arizona, 85032

University of Arizona, Tucson, Arizona

Status

Recruiting

Address

University of Arizona

Tucson, Arizona, 85724

J&L Research, Conway, Arkansas

Status

Recruiting

Address

J&L Research

Conway, Arkansas, 72032

Loma Linda University Health, Loma Linda, California

Status

Recruiting

Address

Loma Linda University Health

Loma Linda, California, 92354

David Geffen School of Medicine at UCLA, Los Angeles, California

Status

Recruiting

Address

David Geffen School of Medicine at UCLA

Los Angeles, California, 90095

UC Davis Medical Center, Sacramento, California

Status

Not yet recruiting

Address

UC Davis Medical Center

Sacramento, California, 95817

University of California San Diego, San Diego, California

Status

Not yet recruiting

Address

University of California San Diego

San Diego, California, 92103

Stanford University Medical Center, Stanford, California

Status

Recruiting

Address

Stanford University Medical Center

Stanford, California, 94305

University of Colorado Denver, Aurora, Colorado

Status

Recruiting

Address

University of Colorado Denver

Aurora, Colorado, 80045

National Jewish Health, Denver, Colorado

Status

Recruiting

Address

National Jewish Health

Denver, Colorado, 80207

Yale University School of Medicine, New Haven, Connecticut

Status

Recruiting

Address

Yale University School of Medicine

New Haven, Connecticut, 06510

Medstar Georgetown University Hospital, Washington, District of Columbia

Status

Recruiting

Address

Medstar Georgetown University Hospital

Washington, District of Columbia, 20007

St. Francis Medical Center, Clearwater, Florida

Status

Recruiting

Address

St. Francis Medical Center

Clearwater, Florida, 33765

Gainesville, Florida

Status

Recruiting

Address

University of Florida Pulmonary, Critical Care & Sleep Medicine Division

Gainesville, Florida, 32610

Jacksonville, Florida

Status

Recruiting

Address

University of Florida Health, Jacksonville

Jacksonville, Florida, 32209

Mayo Clinic, Jacksonville, Florida

Status

Recruiting

Address

Mayo Clinic

Jacksonville, Florida, 32224

Kissimmee, Florida

Status

Recruiting

Address

Pulmonary Disease Specialist, PA d/b/a, PDS Research

Kissimmee, Florida, 34741

University of Miami, Miami, Florida

Status

Not yet recruiting

Address

University of Miami

Miami, Florida, 33125

University of South Florida, Tampa, Florida

Status

Recruiting

Address

University of South Florida

Tampa, Florida, 33606

Emory University, Atlanta, Georgia

Status

Recruiting

Address

Emory University

Atlanta, Georgia, 30322

Piedmont Healthcare, Inc., Austell, Georgia

Status

Recruiting

Address

Piedmont Healthcare, Inc.

Austell, Georgia, 30106

Northwestern University, Chicago, Illinois

Status

Recruiting

Address

Northwestern University

Chicago, Illinois, 60612

Loyola University of Chicago, Maywood, Illinois

Status

Recruiting

Address

Loyola University of Chicago

Maywood, Illinois, 60153

Indiana University School of Medicine, Indianapolis, Indiana

Status

Recruiting

Address

Indiana University School of Medicine

Indianapolis, Indiana, 46202

The University of Kansas Medical Center, Kansas City, Kansas

Status

Recruiting

Address

The University of Kansas Medical Center

Kansas City, Kansas, 66160

University of Maryland, Baltimore, Baltimore, Maryland

Status

Recruiting

Address

University of Maryland, Baltimore

Baltimore, Maryland, 21201

University of Michigan, Ann Arbor, Michigan

Status

Recruiting

Address

University of Michigan

Ann Arbor, Michigan, 48109

Henry Ford Hospital, Detroit, Michigan

Status

Recruiting

Address

Henry Ford Hospital

Detroit, Michigan, 48202

University of Minnesota, Minneapolis, Minnesota

Status

Recruiting

Address

University of Minnesota

Minneapolis, Minnesota, 55455

The Lung Research Center, LLC, Chesterfield, Missouri

Status

Recruiting

Address

The Lung Research Center, LLC

Chesterfield, Missouri, 63017

Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire

Status

Recruiting

Address

Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, 03756

Albany Medical College, Albany, New York

Status

Recruiting

Address

Albany Medical College

Albany, New York, 12208

Pulmonary Health Physicians, PC, Liverpool, New York

Status

Recruiting

Address

Pulmonary Health Physicians, PC

Liverpool, New York, 13088

Pulmonix, LLC, Greensboro, North Carolina

Status

Recruiting

Address

Pulmonix, LLC

Greensboro, North Carolina, 27403

University of Cincinnati, Cincinnati, Ohio

Status

Recruiting

Address

University of Cincinnati

Cincinnati, Ohio, 45267

Ohio State University, Columbus, Ohio

Status

Recruiting

Address

Ohio State University

Columbus, Ohio, 43221

INTEGRIS Baptist Medical Center, Oklahoma City, Oklahoma

Status

Recruiting

Address

INTEGRIS Baptist Medical Center

Oklahoma City, Oklahoma, 73112

Legacy Research Institute, Portland, Oregon

Status

Recruiting

Address

Legacy Research Institute

Portland, Oregon, 97210

The Oregon Clinic, Portland, Oregon

Status

Recruiting

Address

The Oregon Clinic

Portland, Oregon, 97220

Hershey, Pennsylvania

Status

Recruiting

Address

Penn State Milton S. Hershey Medical Center

Hershey, Pennsylvania, 17033

Temple University, Philadelphia, Pennsylvania

Status

Recruiting

Address

Temple University

Philadelphia, Pennsylvania, 19140

Rhode Island Hospital, Providence, Rhode Island

Status

Recruiting

Address

Rhode Island Hospital

Providence, Rhode Island, 02903

Lowcountry Lung and Critical Care, PA, Charleston, South Carolina

Status

Recruiting

Address

Lowcountry Lung and Critical Care, PA

Charleston, South Carolina, 29406

Medical University of South Carolina, Charleston, South Carolina

Status

Recruiting

Address

Medical University of South Carolina

Charleston, South Carolina, 29425

Hendersonville, Tennessee

Status

Recruiting

Address

Tennessee Comprehensive Lung and Sleep Center

Hendersonville, Tennessee, 37075

Vanderbilt University Medical Center, Nashville, Tennessee

Status

Recruiting

Address

Vanderbilt University Medical Center

Nashville, Tennessee, 37204

Cypress, Texas

Status

Recruiting

Address

Houston Pulmonary Sleep, Allergy and Asthma Associates

Cypress, Texas, 77429

Dallas, Texas

Status

Recruiting

Address

Baylor Scott and White Research Institute

Dallas, Texas, 75246

Dallas, Texas

Status

Recruiting

Address

University of Texas Southwestern Medical Center

Dallas, Texas, 75390

Baylor College of Medicine, Houston, Texas

Status

Recruiting

Address

Baylor College of Medicine

Houston, Texas, 77030

University of Texas - Houston, Houston, Texas

Status

Recruiting

Address

University of Texas - Houston

Houston, Texas, 77030

UT Health San Antonio, San Antonio, Texas

Status

Recruiting

Address

UT Health San Antonio

San Antonio, Texas, 78229

Renovatio Clinical, The Woodlands, Texas

Status

Recruiting

Address

Renovatio Clinical

The Woodlands, Texas, 77380

University of Utah Health, Salt Lake City, Utah

Status

Recruiting

Address

University of Utah Health

Salt Lake City, Utah, 84108

The University of Vermont, Burlington, Vermont

Status

Recruiting

Address

The University of Vermont

Burlington, Vermont, 05405

University of Washington, Seattle, Washington

Status

Recruiting

Address

University of Washington

Seattle, Washington, 98195

Medical College of Wisconsin, Milwaukee, Wisconsin

Status

Recruiting

Address

Medical College of Wisconsin

Milwaukee, Wisconsin, 53226

International Sites

Bahia Blanca, Buenos Aires, Argentina

Status

Recruiting

Address

Centro de Investigación Clínica Aplicada - Hospital Regional Español Bahía Blanca

Bahia Blanca, Buenos Aires, B8000AAK

Ciudad Autonoma De Buenos Aires (caba), Buenos Aires, Argentina

Status

Recruiting

Address

Fundacion Respirar - Centro Médico Dra. De Salvo

Ciudad Autonoma De Buenos Aires (caba), Buenos Aires, 1426

Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina

Status

Recruiting

Address

Centro de Investigacion Metabolica 'CINME'

Ciudad Autonoma de Buenos Aires, Buenos Aires, C1027AAP

Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina

Status

Recruiting

Address

Consultorios Medicos. Organización del Buen Ayre. SRL

Ciudad Autonoma de Buenos Aires, Buenos Aires, C1425FVH

Florida, Buenos Aires, Argentina

Status

Recruiting

Address

Centro Medico de Enfermedades Respiratorias

Florida, Buenos Aires, B1602DQD

La Plata, Buenos Aires, Argentina

Status

Recruiting

Address

Centro Platense en Investigaciones Respiratorias

La Plata, Buenos Aires, 1900

Instituto ave Pulmo Fundacion enfisema, Mar del Plata, Buenos Aires, Argentina

Status

Recruiting

Address

Instituto ave Pulmo Fundacion enfisema

Mar del Plata, Buenos Aires, B7602DCK

INSARES, Ciudad de Mendoza, Mendoza, Argentina

Status

Recruiting

Address

INSARES

Ciudad de Mendoza, Mendoza, M5500CCG

Respira Salud Clinica Integral, Godoy Cruz, Provincia De Mendoza, Argentina

Status

Recruiting

Address

Respira Salud Clinica Integral

Godoy Cruz, Provincia De Mendoza, M5501GCA

San Miguel De Tucumán, Tucumán, Argentina

Status

Recruiting

Address

Investigaciones en Patologias Respiratorias

San Miguel De Tucumán, Tucumán, T4000IAR

Westmead Hospital, Westmead, New South Wales, Australia

Status

Recruiting

Address

Westmead Hospital

Westmead, New South Wales, 2145

Mater Health Services Adult Hospital, South Brisbane, Queensland, Australia

Status

Recruiting

Address

Mater Health Services Adult Hospital

South Brisbane, Queensland, 4101

Princess Alexandra Hospital, Woolloongabba, Queensland, Australia

Status

Recruiting

Address

Princess Alexandra Hospital

Woolloongabba, Queensland, 4102

Royal Adelaide Hospital, Adelaide, South Australia, Australia

Status

Recruiting

Address

Royal Adelaide Hospital

Adelaide, South Australia, 5000

Box Hill Hospital, Box Hill, Victoria, Australia

Status

Recruiting

Address

Box Hill Hospital

Box Hill, Victoria, 3128

The Alfred Hospital, Melbourne, Victoria, Australia

Status

Recruiting

Address

The Alfred Hospital

Melbourne, Victoria, 3004

Vina del Mar, Region De Valparaiso, Chile

Status

Recruiting

Address

Centro de Investigacion Clinica V Region CINVEC

Vina del Mar, Region De Valparaiso, 2520997

Centro Investigacion del Maule CIM, Talca, Region Del Maule, Chile

Status

Recruiting

Address

Centro Investigacion del Maule CIM

Talca, Region Del Maule, 3465586

Instituto Nacional del Torax, Santiago, Region Metropolitana, Chile

Status

Not yet recruiting

Address

Instituto Nacional del Torax

Santiago, Region Metropolitana, 7500691

CIMER, Santiago, Region Metropolitana, Chile

Status

Recruiting

Address

CIMER

Santiago, Region Metropolitana, 7500692

M y F estudios clinicos, Santiago, Region Metropolitana, Chile

Status

Recruiting

Address

M y F estudios clinicos

Santiago, Region Metropolitana, 7750495

Hefei, Anhui, China

Status

Not yet recruiting

Address

Second Affiliated Hospital of Anhui Medical University

Hefei, Anhui, 230000

Beijing, Beijing, China

Status

Not yet recruiting

Address

BeiJing Chao-Yang Hospital,Capital medical university

Beijing, Beijing, 100020

China-Japan friendship hospital, Beijing, Beijing, China

Status

Not yet recruiting

Address

China-Japan friendship hospital

Beijing, Beijing, 100029

Peking Union Medical College Hospital, Beijing, Beijing, China

Status

Recruiting

Address

Peking Union Medical College Hospital

Beijing, Beijing, 100730

Guangzhou, Guangdong, China

Status

Not yet recruiting

Address

Nanfang Hospital of Southern Medical University

Guangzhou, Guangdong, 510000

Guangzhou, Guangdong, China

Status

Not yet recruiting

Address

The First Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, 510120

Shenzhen people's hoepital, Shenzhen, Guangdong, China

Status

Not yet recruiting

Address

Shenzhen people's hoepital

Shenzhen, Guangdong, 518020

Henan Provincial People's Hospital, Zhengzhou, Henan, China

Status

Not yet recruiting

Address

Henan Provincial People's Hospital

Zhengzhou, Henan, 450000

Henan Provincial chest hospital, Zhengzhou, Henan, China

Status

Not yet recruiting

Address

Henan Provincial chest hospital

Zhengzhou, Henan, 450003

Wuhan, Hubei, China

Status

Not yet recruiting

Address

Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology

Wuhan, Hubei, 430022

Wuhan, Hubei, China

Status

Recruiting

Address

Union Hospital,Tongji Medical College of Huazhong University of Science and Technology

Wuhan, Hubei, 430022

Changsha, Hunan, China

Status

Not yet recruiting

Address

The Second Xiangya Hospital of Central South University

Changsha, Hunan, 410011

Hohhot, Inner Mongolia, China

Status

Not yet recruiting

Address

Affiliated Hospital of Inner Mongolia Medical University

Hohhot, Inner Mongolia, 10010

Hohhot, Inner Mongolia, China

Status

Not yet recruiting

Address

People's Hospital of Inner Mongolia Autonomous Region

Hohhot, Inner Mongolia, 10020

Nanjing Drum Tower Hospital, Nanjing, Jiangsu, China

Status

Not yet recruiting

Address

Nanjing Drum Tower Hospital

Nanjing, Jiangsu, 210000

Dalian, Liaoning, China

Status

Not yet recruiting

Address

The second hospital of Dalian medical university

Dalian, Liaoning, 116001

Shenyang, Liaoning, China

Status

Not yet recruiting

Address

The First Hospital of China Medical University

Shenyang, Liaoning, 110001

Yinchuan, Ningxia, China

Status

Recruiting

Address

General Hospital of Ningxia Medical University

Yinchuan, Ningxia, 750004

Shanghai, Shanghai, China

Status

Not yet recruiting

Address

Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Shanghai, Shanghai, 200025

Shanghai, Shanghai, China

Status

Not yet recruiting

Address

Shanghai Pulmonary Hospital of Tongji University

Shanghai, Shanghai, 200433

Xi'an, Shanxi, China

Status

Recruiting

Address

The Second Affiliated Hospital of Xi'an Jiaotong University

Xi'an, Shanxi, 710004

Huaxi Hospital of Sichuan University., ChenDu, Sichuan, China

Status

Not yet recruiting

Address

Huaxi Hospital of Sichuan University.

ChenDu, Sichuan, 6100141

Tianjin, Tianjin, China

Status

Recruiting

Address

General Hospital of Tianjin Medical University

Tianjin, Tianjin, 300052

Hangzhou First People's Hospital, Hangzhou, Zhejiang, China

Status

Recruiting

Address

Hangzhou First People's Hospital

Hangzhou, Zhejiang, 310006

Nemocnice Jihlava, Jihlava, Czechia

Status

Recruiting

Address

Nemocnice Jihlava

Jihlava, , 625 00

Bron, France

Status

Recruiting

Address

Hôpital Cardio-Vasculaire et Pneumologique Louis Pradel

Bron, , 69677

Montpellier, France

Status

Recruiting

Address

C.H.R.U. de Montpellier - Hôpital Lapeyronie

Montpellier, , 34295

CHU de Nice Hôpital Pasteur, Nice, France

Status

Recruiting

Address

CHU de Nice Hôpital Pasteur

Nice, , 06000

Hôpital Bichat - Claude Bernard, Paris, France

Status

Recruiting

Address

Hôpital Bichat - Claude Bernard

Paris, , 75018

CHU de Reims Hopital Maison Blanche, Reims, France

Status

Recruiting

Address

CHU de Reims Hopital Maison Blanche

Reims, , 51092

CHU de Rennes Hôpital Pontchaillou, Rennes, France

Status

Recruiting

Address

CHU de Rennes Hôpital Pontchaillou

Rennes, , 35033

Essen, Germany

Status

Recruiting

Address

Ruhrlandklinik-Universitaetsmedizin Essen

Essen, , 45239

Gießen, Germany

Status

Recruiting

Address

Agaplesion Evangelisches Krankenhaus Mittelhessen

Gießen, , 035398

Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany

Status

Recruiting

Address

Universitätsklinikum Hamburg-Eppendorf

Hamburg, , 20246

Queen Mary Hospital, Central, Hong Kong

Status

Recruiting

Address

Queen Mary Hospital

Central, ,

Princess Margaret Hospital, Hong Kong, Hong Kong

Status

Recruiting

Address

Princess Margaret Hospital

Hong Kong, ,

Tuen Mun Hospital, Hong Kong, Hong Kong

Status

Recruiting

Address

Tuen Mun Hospital

Hong Kong, ,

Petz Aldar County Teaching Hospital, Gyor, Hungary

Status

Recruiting

Address

Petz Aldar County Teaching Hospital

Gyor, , 9023

Fejer Megyei Szent Gyorgy kh, Szekesfehervar, Hungary

Status

Recruiting

Address

Fejer Megyei Szent Gyorgy kh

Szekesfehervar, , 8000

Gaspare Rodiloco Hospital, Catania, Italy

Status

Recruiting

Address

Gaspare Rodiloco Hospital

Catania, , 95123

AOU Policlinico di Modena, Modena, Italy

Status

Recruiting

Address

AOU Policlinico di Modena

Modena, , 41124

Monaldi Hospital, Naples, Italy

Status

Recruiting

Address

Monaldi Hospital

Naples, , 80131

IRCCS Fondazione San Matteo di Pavia, Pavia, Italy

Status

Recruiting

Address

IRCCS Fondazione San Matteo di Pavia

Pavia, , 27100

Bucheon-si, Gyeonggi-do, Korea, Republic of

Status

Recruiting

Address

Soonchunhyang University Bucheon Hospital

Bucheon-si, Gyeonggi-do, 14579

Bucheon-si, Gyeonggi-do, Korea, Republic of

Status

Recruiting

Address

The Catholic University of Korea, Bucheon St. Mary's Hospital

Bucheon-si, Gyeonggi-do, 14647

Seongnam-si, Gyeonggi-do, Korea, Republic of

Status

Recruiting

Address

Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, 13620

Ajou University Hospital, Suwon-si, Gyeonggi-do, Korea, Republic of

Status

Not yet recruiting

Address

Ajou University Hospital

Suwon-si, Gyeonggi-do, 16499

Inje University Busan Paik Hospital, Busan, Korea, Republic of

Status

Recruiting

Address

Inje University Busan Paik Hospital

Busan, , 47392

Gachon University Gil Medical Center, Incheon, Korea, Republic of

Status

Recruiting

Address

Gachon University Gil Medical Center

Incheon, , 21565

Korea University Anam Hospital, Seoul, Korea, Republic of

Status

Recruiting

Address

Korea University Anam Hospital

Seoul, , 2841

Seoul National University Hospital, Seoul, Korea, Republic of

Status

Recruiting

Address

Seoul National University Hospital

Seoul, , 3080

Asan Medical Center, Seoul, Korea, Republic of

Status

Recruiting

Address

Asan Medical Center

Seoul, , 5505

Samsung Medical Centerx, Seoul, Korea, Republic of

Status

Recruiting

Address

Samsung Medical Centerx

Seoul, , 6351

Hotel Dieu De France, Beirut, Lebanon

Status

Recruiting

Address

Hotel Dieu De France

Beirut, ,

St. Antonius Ziekenhuis BV, Nieuwegein, Netherlands

Status

Recruiting

Address

St. Antonius Ziekenhuis BV

Nieuwegein, , 3435

Canisius-Wilhelmina Ziekenhuis, Nieuwegein, Netherlands

Status

Recruiting

Address

Canisius-Wilhelmina Ziekenhuis

Nieuwegein, , 6533

Clinica San Pablo, Lima, Peru

Status

Recruiting

Address

Clinica San Pablo

Lima, , 150140

Hospital Guillermo Almenara Irygoyen, Lima, Peru

Status

Recruiting

Address

Hospital Guillermo Almenara Irygoyen

Lima, , 15033

Clinica Providencia, Lima, Peru

Status

Recruiting

Address

Clinica Providencia

Lima, , 15088

Lima, Peru

Status

Recruiting

Address

Hospital Nacional Cayetano Heredia / Servicio de Inmunología y Reumatología

Lima, , 15102

Centro de Investigacion Ricardo Palma, San Isidro, Peru

Status

Recruiting

Address

Centro de Investigacion Ricardo Palma

San Isidro, , 150131

Clinica La luz, Santa Beatriz, Peru

Status

Recruiting

Address

Clinica La luz

Santa Beatriz, , 15046

Regional Clinical Hospital #3, Chelyabinsk, Russian Federation

Status

Not yet recruiting

Address

Regional Clinical Hospital #3

Chelyabinsk, , 454106

Medical Association "NEW HOSPITAL", Ekaterinburg, Russian Federation

Status

Not yet recruiting

Address

Medical Association "NEW HOSPITAL"

Ekaterinburg, , 620109

Kazan, Russian Federation

Status

Not yet recruiting

Address

Kazan State Medical University based on Republican Clinical Hospital

Kazan, , 420029

Clinical Hospital #3, Kemerovo, Russian Federation

Status

Not yet recruiting

Address

Clinical Hospital #3

Kemerovo, , 650000

Moscow, Russian Federation

Status

Not yet recruiting

Address

Euromedservice, Clinical and Diagnostic Center

Moscow, , 115419

MONIKI, Moscow, Russian Federation

Status

Not yet recruiting

Address

MONIKI

Moscow, , 129110

Omsk, Russian Federation

Status

Not yet recruiting

Address

City Clinical Hospital #1 n.a. A.N. Kabanov

Omsk, , 644112

Republican Hospital named V.A. Baranov, Petrozavodsk, Russian Federation

Status

Not yet recruiting

Address

Republican Hospital named V.A. Baranov

Petrozavodsk, , 185019

FSBEI HE First Pavlov Medical University, Saint-Petersburg, Russian Federation

Status

Not yet recruiting

Address

FSBEI HE First Pavlov Medical University

Saint-Petersburg, , 197022

Vvedenskaya hospital, St. Petersburg, Russian Federation

Status

Not yet recruiting

Address

Vvedenskaya hospital

St. Petersburg, , 191180

Medical Center "Reavita Med SPb", St. Petersburg, Russian Federation

Status

Not yet recruiting

Address

Medical Center "Reavita Med SPb"

St. Petersburg, , 194354

Hospital Universitario de Bellvitge, Barcelona, Spain

Status

Recruiting

Address

Hospital Universitario de Bellvitge

Barcelona, , 08907

Hospital Clinic de Barcelona, Barcelona, Spain

Status

Recruiting

Address

Hospital Clinic de Barcelona

Barcelona, , 8036

Hospital Universitaio de La Princesa, Madrid, Spain

Status

Recruiting

Address

Hospital Universitaio de La Princesa

Madrid, , 28006

Madrid, Spain

Status

Recruiting

Address

Hospital General Universitario Gregorio Maranon

Madrid, , 28007

Madrid, Spain

Status

Recruiting

Address

Hospital Universitario Quironsalud Madrid

Madrid, , 28223

Santander, Spain

Status

Recruiting

Address

Hospital Universitario Marques de Valdecilla

Santander, , 39008

Taichung Veterans General Hospital, Taichung, Taiwan

Status

Recruiting

Address

Taichung Veterans General Hospital

Taichung, , 40705

Taipei, Taiwan

Status

Recruiting

Address

Taipei Medical University - Shuang-Ho Hospital, Ministry of Health and Welfare

Taipei, , 23561